Personal Data

Business Address:
Dept. of Human and Animal Physiology, Kazan Federal University,
Kremlevskaya str. 18, Kazan, Russia 4200008
Phone: +7 (843) 233 78 24
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Date of Birth: 28.12.1968


Education and Academic Degrees

  • 1978-1982 BS Kazan School №18, Russia
  • 1986 – 1991 Undergraduate of Kazan State University, Biological faculty
  • 1991-1993 Post graduate student of Kazan State University, Dept. of Dept. of Human and Animal Physiology
  • 1995 - Ph.D.thesis “The effects of fenolic substances on ionic currents of motor nerve endings” Dept. of Human and Animal Physiology, Kazan State University
  • 1993-2001 – Professor Assistant of Dept. Dept. of Human and Animal Physiology
  • Since 2001 - Associate Professor of Dept. of Human and Animal Physiology
  • Since 2009 – Professor of Dept. of Human and Animal Physiology
  • Since 2012 – Head of Dept. of Human and Animal Physiology


Field of studies

Neuroscience, Gasotransmitters, physiology of excitable cells


Areas of Specializations

Synaptic transmission, presynaptic mechanisms of modulation of transmitter release, vesicular cycle, ion channels, Ca-activated potassium channels, gasotransmitters, anesthetics and ethanol action on brain activity, regulation of contractility of smooth muscles and myocardium


Research skills

Electrophysiology recording (intracellular or extracellular recording techniques), patch-clamp technique, cell culture, recordings of brain activity in vivo



  • 1992-1993 - Soros postgraduate student
  • 2000-2002 – Special scholarship of President of Russian Federation for young scientists
  • 2002 - Special fellowship for young lecturer of Potanin’s fund
  • 2001 - №01-04-06292 Grant of Russian Foundation of Basic Researchers for young scientists
  • 2003-2005 - №03-04-96252 “Second messenger system as a target of action of biological active compounds”
  • 2006-2008 - N 06-04-49125 “The role of carbon monoxide in the modulation of synaptic transmission”
  • 2009-2011 - 09-04-00748-а Нydrogen sulfide as novel endogenous modulators of synaptic transmission
  • 2012- 2014 12-04-00960- Hydrogen sulfide as a gasotransmitter in excitable tissues
  • 06.11.2007, 2008, 2010 - Bundesministerium für Wissenschaft und Forschung (BMWF), Austria – invited lecture,
  • 2007 - 2014 Hirnforschungseminare des Projekteams “Hirnforschung in Osterreich”, "Stifungs - und Förderungsgesellschaft" - research grants from University of Salzburg
  • 2014-2016 - Russian Scientific Fund №14-15-00618


Supervision of PHD students

  • Yakovlev A.V. (Associate professor, Dept of Human and Animal Physiology, Kazan Federal University);
  • Yakovleva O.V. (Senior teacher, Dept of Human and Animal Physiology, Kazan Federal University );
  • E.V. Gerasimova (Associate professor, Human and Animal Physiology, Kazan Federal University),
  • Khaertdinov N.N (Professor assistant, Human and Animal Physiology, Kazan Federal University),
  • present J.Lebedeva, Mustafina A., Koroleva K., Sabirullina G., Lifanova A


Organisation of international conferences

  • 13th annual Symposium for Biology students of Europe "SymBioSe 2009" “Biology:expansion of borders". – Kazan, 2009
  • International Meeting “ Developmental Physiology”, Jalchik Meeting Kazan 2012
  • UK-Russia Frontiers of Science Symposium - joint Symposium of the RF Academy of Science and the Royal Society of UK, Kazan, 2013
  • International school-conference “From neuron to brain”, Kazan, 2013
  • International Symposium “Gasotransmitters: physiology and pathophysiology”, Kazan 2014



Isoflurane suppresses early cortical activity

Guzel Sitdikova, Andrei Zakharov, Sona Janackova, Elena Gerasimova, Julia Lebedeva, Ana R. Inacio, Dilyara Zaynutdinova, Marat Minlebaev, Gregory L. Holmes, Roustem Khazipov; Annals of Clinical and Translational Neurology 2014; 1(1): 15–26 PDF

Gamma Oscillations in the Somatosensory Cortex of Newborn Rats

E. V. Gerasimova, A. V. Zakharov, Yu. A. Lebedeva, A. R. Inacio, M. G. Minlebaev, G. F. Sitdikova, and R. N. Khazipov; Bulletin of Experimental Biology and Medicine, Vol. 156, No. 3, January, 2014 PDF


Khalilov I.A., Sitdikova G.F., Zefirov A.L. Influence of catechol on neuromuscular transmission // Neirofiziologiya/Neurophysiology (Kiev) - 1993.- v.1, N6.- P.405-408 (in Russian)

Sitdikova GF, Khalilov IA, Zefirov AL. The effect of phenol on the ion currents of the frog motor nerve ending Fiziol Zh Im I M Sechenova. 1996 Jul;82(7):78-84. (in Russian)

Zefirov A.L., Moukhamediarov M.A., Sitdikova G.F. Changes in the asynchronicity of transmitter release at the neuromuscular junction during prolonged high frequency stimulation// Neirofiziologiya/Neurophysiology (Kiev) 2002., V.34, N2/3 P 273-275

Yakovlev A.V., Sitdikova G.F., Zefirof A.L. Role the cGMP- and cAMP-dependent systems in effects of nitricoxide on transmitter release and potassium currents in the frog neuromuscular junction. Neirofiziologiya/Neurophysiology (Kiev) 2002 T.34, N.2/3, pp.267-269.

Yakovlev AV, Sitdikova GF, Zefirov AL Role of cyclic nucleotides in mediating the nitric oxide (II) effects on transmitter release and the electrogenesis of motor nerve endings. Dokl Biol Sci. 2002 Jan-Feb;382:11-4

Zefirov AL, Sitdikova GF. [Ion channels in nerve ending] Usp Fiziol Nauk. 2002 Oct-Dec;33(4):3-33. Review (in Russian)

Sitdikova GF, Yakovlev AV, Zefirov AL, Arkhipova OV. The effects of L- and D-stereoisomers on the transmitter secretion and ionic currents in the motor nerve ending. Dokl Biol Sci. 2003 Nov-Dec;393:523-6

Zefirov AL, Grigor'ev PN, Petrov AM, Minlebaev MG, Sitdikova GF [Analysis of living motor nerve ending of a frog by endocytotic fluorescent marker FM 1-43] Tsitologiia. 2003; 45(12):1163-71. (in Russian)

Sitdikova GF, Grishin SN, Zefirov AL. 2005 Presynaptic effects of carbon monoxide in the myoneural synapse of the frog. Dokl Biol Sci. Jul-Aug;403:233-6.

Yakovlev A., Sitdikova G., Zefirov A 2005 [Intracellular presynaptic mechanisms of nitric oxide action in frog neuromuscular junction]//Neirochimia, т.22, №1, с.81-87. (in Russian)

G.F.Sitdikova, A.L.Zefirov 2006 [Gaseous messengers in nervous system] Fiziol Zh Im I M Sechenova. V.97, №7, p.872-882 Russian

Arkhipova OV, Grishin SN, Sitdikova GF, Zefirov AL The presynaptic effects of arachidonic acid and prostaglandin E2 at the frog neuromuscular junction. Neurosci Behav Physiol. 2006 Mar; 36(3):307-12.

O.V. Yakovleva, G.F. Sitdikova, E.V. Gerasimova, A.L. Zefirov Fatty Acids Modulate Transmitter Release and Functioning of Potassium Channels in Motor Nerve Endings//Neurochemical Journal, 2007, Vol. 1, No. 2, pp. 143–149. (Original Russian Text, published in Neirokhimiya, 2006, Vol. 23, No. 4, pp. 294–300)

Sitdikova GF, Islamov RR, Mukhamedyarov MA, Permyakova VV, Zefirov AL, Palotas A. Modulation of neurotransmitter release by carbon monoxide at the frog neuromuscular junction. Curr Drug Metab. 2007 Feb;8(2):177-84.

E. V. Gerasimova, G. F. Sitdikova, A. L. Zefirov 2008 Hydrogen Sulfide as an Endogenous Modulator of Mediator Release in the Frog Neuromuscular Synapse//Neurochemical Journal, Vol. 2, 1–2, pp. 120–126.

Zefirov AL, Zakharov AV, Mukhametzianov RD, Petrov AM, Sitdikova GF. [Vesicle cycle in mouse diaphragm motor nerve terminals]. Ross Fiziol Zh Im I M Sechenova. 2008 Feb;94(2):129-41. Russian

Petrov AM, Giniatullin AR, Sitdikova GF, Zefirov AL The role of cGMP-dependent signaling pathway in synaptic vesicle cycle at the frog motor nerve terminals. J Neurosci. 2008 Dec 3;28(49):13216-22.

Zefirov AL, Zakharov AV, Mukhametzyanov RD, Petrov AM, Sitdikova GF The vesicle cycle in motor nerve endings of the mouse diaphragm. Neurosci Behav Physiol. 2009 Mar;39(3):245-52

Sitdikova GF, Weiger TM, Hermann A. Hydrogen sulfide increases calcium-activated potassium (BK) channel activity of rat pituitary tumor cells. Pflugers Arch. 2010 Feb;459(3):389-97.

Abramochkin DV, Haertdinov NN, Porokhnya MV, Zefirov AL, Sitdikova GF Carbon monoxide affects electrical and contractile activity of rat myocardium . J Biomed Sci. 2011 Jun 15;18:40

Abramochkin DV, Haertdinov NN, Porokhnya MV, Zefirov AL, Sitdikova GF. Changes in the electrical and contractile activities of rat atrial myocardium caused by carbon monoxide. Dokl Biol Sci. 2011 Jul-Aug;439:187-90.

G. F. Sitdikova, A. V. Yakovlev , Y. G. Odnoshivkin, A. L. Zefirov Effects of Hydrogen Sulfide on the Exo and Endocytosis of Synaptic Vesicles in Frog Motor Nerve Endings// Neurochemical Journal, 2011, Vol. 5, No. 4, pp. 245–250.

Sitdikova GF, Khaertdinov NN, Zefirov AL Role of calcium and potassium channels in effects of hydrogen sulfide on frog myocardial contractility . Bull Exp Biol Med. 2011 Jun;151(2):163-6.

Valiullina F.F., Sitdikova G.F. Effects and mechanisms of nitric oxide (II) action on transmitter release in mouse motor nerve terminal// Neurophysiology, Vol. 44, No. 6, December, 2012, P. 490-492

N. N. Khaertdinov, , D. R. Ahmetshina, , A. L. Zefirov, G. F. Sitdikova Hydrogen Sulfide in Regulation of Frog Myocardium Contractility //Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2013, Vol. 7, No. 1, pp. 52–57

O. V. Yakovleva , M. U. Shafigullin, and G. F. Sitdikova The role of Nitric oxide in regulation of neurotransmitter release and processes of exo- and endocytosis of synaptic vesicles in mouse motor nerve endings Neurochemical journal, 2013, V.7 N2 P 103-110

O. B. Mitrukhina, A. V. Yakovlev, and G. F. Sitdikova The Effects of Hydrogen Sulfide on the Processes of Exo_ and Endocytosis of Synaptic Vesicles in the Mouse Motor Nerve Endings Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2013, Vol. 7, No. 2, pp. 170–173.

EV Gerasomova, OV Yakovleva, AL, Zefirov, GF Sitdikova The role of ryanodine receptors in the effects of hydrogen sulfide on transmitter release in frog motor nerve endings Bulletin of Experimental Biology and Medicine 2013 V155. №1 P. 14-17

M. Y. Shafigullin, R. A. Zefirov, G. I. Sabirullina, A. L. Zefirov and G. F. Sitdikova Effects of a Hydrogen Sulfi de Donor on Spontaneous Contractile Activity of Rat Stomach and Jejunum // Bulletin of Experimental Biology and Medicine, Vol. 157, No. 3, July, 2014 PHYSIOLOGY P302-306

Sitdikova GF, Fuchs R, Kainz V, Weiger TM and Hermann A (2014) Phosphorylation of BK channels modulates the sensitivity to hydrogen sulfide (H2S). Front. Physiol. 5:431.

Mechanisms by which calcium receptor stimulation modifies electromechanical coupling in isolated ventricular cardiomyocytes. Schreckenberg R, Dyukova E, Sitdikova G, Abdallah Y, Schlьter KD.Pflugers Arch. 2014 Apr 1.